Adipose tissue inflammation and ectopic lipid accumulation [Review]
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چکیده
منابع مشابه
Adipose tissue inflammation and ectopic fat accumulation
Obesity may be viewed as a state of chronic, low-grade inflammation, which plays an important role in the development of the metabolic syndrome. Indeed, unbalanced production of proand anti-inflammatory adipocytokines seen in visceral fat obesity plays a critical role in the pathophysiology of the metabolic syndrome. Recent evidence has revealed that adipose tissue macrophages may participate i...
متن کاملAdipose tissue, inflammation and atherosclerosis.
Metabolic syndrome is associated with dysfunctional adipose tissue that is most likely a consequence of the enlargement of adipocytes and infiltration of macrophages into adipose tissue. Obesity and ectopic lipid deposition are major risk factors for diseases ranging from insulin resistance to type 2 diabetes and atherosclerosis. Enlargement of adipocytes, due to impaired adipocyte differentiat...
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OBJECTIVE Macrophage recruitment to adipose tissue is a reproducible feature of obesity. However, the events that result in chemokine production and macrophage recruitment to adipose tissue during states of energetic excess are not clear. Sirtuin 1 (SirT1) is an essential nutrient-sensing histone deacetylase, which is increased by caloric restriction and reduced by overfeeding. We discovered th...
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Human adipose tissue represents an abundant, practical and appealing source of donor tissue for autologous cell replacement. Recent findings have shown that stem cells within the stromalvascular fraction of adipose tissue display a multilineage developmental potential. Adipose tissue-derived stem cells can be differentiated towards adipogenic, osteogenic, chondrogenic,myogenic and neurogenic li...
متن کاملAdipose Tissue Inflammation and Insulin Resistance
A sustained increase in body mass, particularly fat mass, an unhealthy diet and a sedentary lifestyle trigger metabolic alterations such as metabolic syndrome, obesity, and type 2 diabetes mellitus (2DM). These metabolic conditions increase the cardiovascular disease risks and have become epidemic public health problems (Grundy 2002). Individuals who are overweight and obese are associated with...
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ژورنال
عنوان ژورنال: Endocrine Journal
سال: 2012
ISSN: 0918-8959,1348-4540
DOI: 10.1507/endocrj.ej12-0271